ADME-Enabling Technologies in Drug Design and Development
By Sekhar Surapaneni, Donglu Zhang
Publisher: Wiley
Final Release Date: April 2012
Pages: 800

A comprehensive guide to cutting-edge tools in ADME research

The last decade has seen tremendous progress in the developmentof analytical techniques such as mass spectrometry and molecularbiology tools, resulting in important advances in drug discovery,particularly in the area of absorption, distribution, metabolism,and excretion (ADME).

ADME-Enabling Technologies in Drug Design and Developmentfocuses on the current state of the art in the field, presenting acomprehensive review of the latest tools for generating ADME datain drug discovery. It examines the broadest possible range ofavailable technologies, giving readers the information they need tochoose the right tool for a given application, a key requisite forobtaining favorable results in a timely fashion for regulatoryfilings. With over thirty contributed chapters by an internationalteam of experts, the book provides:

  • A thorough examination of current tools, covering bothelectronic/mechanical technologies and biologically based ones

  • Coverage of applications for each technology, including keyparameters, optimal conditions for intended results, protocols, andcase studies

  • Detailed discussion of emerging tools and techniques, from stemcells and genetically modified animal models to imagingtechnologies

  • Numerous figures and diagrams throughout the text

Scientists and researchers in drug metabolism, pharmacology,medicinal chemistry, pharmaceutics, toxicology, and bioanalyticalscience will find ADME-Enabling Technologies in Drug Design andDevelopment an invaluable guide to the entire drug developmentprocess, from discovery to regulatory issues.

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